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Diablo 4 Season 11 Legendary Rune Farming Guide: How To Obtain Infinite Runes With Divine Gifts?

Posted: Dec 18, 2025 Views: 63

Since the introduction of Rune system in Diablo 4, runes have been a coveted resource for almost every player. This is not only because they can activate powerful Runewords, providing synergistic buffs for character builds, but more importantly, they are essential consumables for crafting specific Mythic Uniques.

With the developers significantly increasing monster strength and readjusting defensive mechanisms in Diablo 4 Season 11, the days of clearing Pits 100+ without requiring Mythic items may be over. Therefore, runes have become crucial for improving survivability in the endgame, often surpassing the power of support gems, especially in armor sockets.

So, here we introduce a new Legendary Rune farming method introduced in Season 11, which is likely the fastest way to obtain runes in Diablo 4 currently. We will explain step-by-step how to set it up and how to farm efficiently. Let's begin.

Diablo 4 Season 11 Legendary Rune Farming Guide: How To Obtain Infinite Runes With Divine Gifts?

Step-by-Step Guide

Upgrading Essence Of Pain

First, you need to upgrade your Essence of Pain Divine Gift to level five. This allows players to have a chance to obtain dropped Socketables such as Royal Gems, Gem Fragments, and Legendary Runes when defeating Pangs of Duriel. However, this is not the only reason we choose this Divine Gift; we will explain later.

To upgrade this Divine Gift, you need to kill monsters in Helltide. When monsters in Helltide die, there is a chance they will provide experience points for this Divine Gift.

However, a more efficient way to upgrade it is to kill as many Duriel bosses as possible in Helltide, as he is guaranteed to provide experience points for this Divine Gift.

Diablo 4 Essence of Pain Divine Gift

Collecting Corrupted Horn Of Duriel

While upgrading your Divine Gift, it is recommended that you collect as many Corrupted Horns of Duriel from the Duriel boss as possible, as you will need them later.

However, please note that each person can only carry a maximum of 20 Corrupted Horns of Duriel. So, if you find that Duriel is no longer dropping this item, it may be because your inventory is full. It's time to clear your inventory.

Once you have upgraded your Divine Gift to the maximum level five, you should place it in the Purified Gift slots. 

Defeat Azmodan & Open Duriel's Chest

Next, head south of Zarbinzet to summon the open-world version of Azmodan. There are usually many players farming there, so defeating him shouldn't be too difficult.

After defeating the boss, three chests will drop for you to choose from. Open Duriel's Hoard chest, which requires five Corrupted Horns of Duriel. However, since the newly upgraded Essence of Pain Divine Gift also works on this chest, it guarantees you at least one Legendary Rune. This is your main source of runes.

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Farming Loop

Next, we'll discuss how to continuously open this chest.

These chests also contain boss materials, more specifically, a large amount of Living Steel. Some players have even obtained over 40 Living Steels from a single Duriel chest, which is a considerable amount of wealth. Therefore, in addition to aiming for Diablo 4 Legendary Runes from this chest, Living Steels are also important items worth collecting.

Why? Because we need to use these Living Steels to obtain more Corrupted Horns of Duriel.

After opening all the Duriel chests, you should have a large amount of Living Steel in your inventory. Next, we will use all of this Living Steel to open Grigoire's Hoard chest.

Travel to Grigoire's lair, defeat him, and open his chests as many times as possible, using up all your Living Steel. During this process, you will obtain a large amount of Shards of Agony and some Stygian Stones. You should convert these Stygian Stones into Shards of Agony, and then head to Duriel's lair. Note that this is not the Duriel in Helltide, but the Lair version of the Duriel boss. After defeating him, you can use your Shards of Agony to open the Hoard chests as many times as possible.

We do this because the Duriel Lair boss also drops Corrupted Horns of Duriel. This allows you to collect enough materials without too much effort and provides the motivation to continue farming.

Diablo 4 Azmodan Boss

In short, once you have replenished your stock of Corrupted Horns of Duriel, immediately summon Azmodan boss, defeat him, and open as many Duriel chests as possible. Each time you open a chest, you are guaranteed to get a Legendary Rune. This creates a complete farming cycle:

  1. Use your Corrupted Horn of Duriel to open the Duriel chest at the Azmodan boss location to obtain a large amount of Living Steels and Legendary Runes.
  2. Use these Living Steels to summon and defeat Grigoire, which will grant you a large number of Shards of Agony. You can then use these to summon a higher difficulty version of Duriel to obtain some dropped Corrupted Horns of Duriel.
  3. Then, return to the open-world version of Azmodan and use the Corrupted Horn of Duriel to open the chest for guaranteed runes.
  4. If you don't get enough Living Steels from the chest, you can supplement them from Helltide chests.

Duriel Chest vs. Kurast Undercity Farming

Finally, some players might question whether this farming method is as good as farming the Tribute of Harmony in the Kurast Undercity. Diablo 4 Season 11 significantly enhanced the Kurast Undercity, especially Tribute of Harmony and Tribute of Mystique, greatly increasing the drop rate of Legendary Runes and other valuable loot. So why would we choose the more cumbersome Duriel boss chest farming method to obtain runes?

The reality is that Tribute of Harmony is difficult to find and limited in quantity, while this farming cycle is sustainable and unlimited. Therefore, it definitely has many advantages.

In short, this is a currently viable and relatively easy rune farming method that allows you to obtain endless Legendary Runes in the early stages of D4S11. If you are lacking specific runes, why not give it a try!

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